https://www.ledolab.org/home daily 1.0 2022-08-11 https://images.squarespace-cdn.com/content/v1/6267215cb9ef2f2b43c0aef3/12e75c48-1eb7-40fb-9a30-2a0eae1f0bd5/microglia.jpeg Home The pursuit for memory enhancement is necessitated by the increasingly aging population and increasingly prevalent memory disorders such as Alzheimer’s disease (AD). Advancing our understanding of the molecular basis of cognition is crucial for the development of new approaches to tackle cognitive impairment. Historically, brain neuroimmunology was primarily focused on how the immune system interacts with the nervous system in pathological conditions such as neuroinflammation. More recently, advances in neuroscience and immunology have revealed a bidirectional communication between neurons and immune cells, which is required for brain homeostasis. To date, neuro-immune interactions are increasingly recognized to be dynamically involved in cognition. Importantly, the molecular mechanisms by which neuro-immune interactions modulate cognitive processes in health and disease are still largely unexplored. To advance our understanding of the molecular basis of cognition it is imperative to define the molecular mechanisms by which underlying neuro-immune interactions operate. Recently, Dr. Ledo’s research uncovered an unpredicted neuro-immune pathway that can enhance cognition in mice . These findings support the hypothesis that brain neuro-immune interactions are critically involved in cognition. Dr. Ledo’s Laboratory will continue to explore new pathways that can enhance memory in mice by utilizing innovative multidisciplinary approaches. https://www.ledolab.org/publications daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/2b138b19-e39b-4aaa-bfe4-ee168dac9208/20140301_Trade+151_0124+1.jpg https://www.ledolab.org/contact daily 0.75 2023-09-27 https://images.squarespace-cdn.com/content/v1/6267215cb9ef2f2b43c0aef3/d81d22cd-d13b-4fcb-a466-2a751c62e334/charleston+pinapple.jpeg Contact - Contact us Jose H.Ledo, PhD ledo@musc.edu 123 Ashley Ave - Basic Research Building (BSB) - Room 410A Medical University of South Carolina (MUSC) Charleston, SC https://www.ledolab.org/team daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/6267215cb9ef2f2b43c0aef3/ac01a172-0a5b-419a-a282-eadea88a0af2/Passport+Photo+Jose+2.jpg Team - Jose H.Ledo, PhD Principal Investigator Google Scholar Before joining MUSC as Assistant Professor in 2022, Dr. Ledo conducted his postdoctoral studies (2015-2022) at The Rockefeller University under the mentorship of the Nobel laureate the late Paul Greengard and co-mentorship of Dr. Beth Stevens at Harvard University . Dr. Ledo studies are focused on the emerging roles of brain neuro-immune interactions in synaptic plasticity, memory and Alzheimer’s Disease. https://www.ledolab.org/research daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847889324-DFHCXJY7BA7YLNZ26RDC/image-asset.jpeg Research - Project 2 COMING SOON https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847890165-I7LPX06YA44DBGGFPSGA/image-asset.jpeg Research - Project 1 COMING SOON https://www.ledolab.org/resources daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/25a53dcc-a4e0-4742-848d-aabb36f7ec37/image-asset+%283%29.jpeg https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/6b4f26e4-fadf-426a-8f71-0527a033d52c/Aro+Ha_0010+1.jpg https://www.ledolab.org/philosophy daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/d6069999-a012-4166-97ca-493710b6357b/Aro+Ha_0387.jpg https://www.ledolab.org/open-positions daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/25a53dcc-a4e0-4742-848d-aabb36f7ec37/image-asset+%283%29.jpeg https://www.ledolab.org/news daily 0.75 2022-08-11 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/2b138b19-e39b-4aaa-bfe4-ee168dac9208/20140301_Trade+151_0124+1.jpg